Israeli data: How can efficacy vs. severe disease be strong when 60% of hospitalized are vaccinated?

Link: https://www.covid-datascience.com/post/israeli-data-how-can-efficacy-vs-severe-disease-be-strong-when-60-of-hospitalized-are-vaccinated

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These efficacies are quite high and suggests the vaccines are doing a very good job of preventing severe disease in both older and young cohorts. These levels of efficacy are much higher than the 67.5% efficacy estimate we get if the analysis is not stratified by age. How can there be such a discrepancy between the age-stratified and overall efficacy numbers?

This is an example of Simpson’s Paradox, a well-known phenomenon in which misleading results can sometimes be obtained from observational data in the presence of confounding factors.

Author(s): Jeffrey Morris

Publication Date: 17 August 2021

Publication Site: Covid-19 Data Science